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Topic: HPLC Sample filtration? (Read 56 times) previous topic - next topic

HPLC Sample filtration?

Hello everyone :)
Do anyone filter their blood/urine/food_extract samples before injection in their LC-MS system?
We are hesitating about which type of filter to use (reg cellulose, nylon, PFTE, ...) and the porosity (0.2 or 0.45 micron).
We are planning to analyse 700+ samples of milk or yoghurt for untargeted metabolomics and want to avoid damaging our column (it is a 1.8 micron column)
Do you have some recomendations?
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Grégory Pimentel, PhD
Functional Nutritional Biology research group
Agroscope, Hauptgebäude
Schwarzenburgstrasse 161
3003 Bern
Mail: gregory.pimentel@agroscope.admin.ch